AI Can Now Predict Cancer

AI Predicts Cancer Survival from Selfies: Lancet Study Unveils FaceAge Tool

A groundbreaking Lancet Digital Health study published May 8, 2025, demonstrates that an AI tool—dubbed FaceAge—can analyze a simple selfie to estimate a cancer patient’s biological age and accurately predict their survival outcomes. FaceAge, trained on nearly 59,000 healthy-individual photographs and validated on over 6,000 cancer patients, outperforms clinicians in forecasting six-month survival, boosting accuracy from 61% to 80% when used alongside standard assessments (Financial Times, Mass General Brigham).

Table of Contents

  1. AI’s Emerging Role in Oncology Prognosis
  2. The Lancet Study at a Glance

    1. Study Design and Patient Cohorts
    2. Developing the FaceAge Algorithm

  3. Key Findings and Performance Metrics

    1. Accuracy Gains Over Clinicians
    2. FaceAge Discrepancy and Survival Trends

  4. Clinical Implications and Applications

    1. Integrating FaceAge into Care Pathways
    2. Ethical, Privacy, and Bias Considerations

  5. Expert Commentary and Future Directions
  6. Conclusion: Toward Personalized Prognosis

AI’s Emerging Role in Oncology Prognosis

Artificial intelligence (AI) is rapidly reshaping how clinicians assess cancer prognosis, moving beyond traditional biomarkers and imaging to harness everyday data, like a patient’s selfie, to gauge disease risk. By quantifying “biological age” rather than relying solely on chronological age, AI promises a more nuanced view of patient health, potentially guiding tailored treatment plans. The recent Lancet Digital Health publication of the FaceAge study exemplifies this shift, demonstrating that a selfie can be a potent biomarker for survival prediction in oncology (euronews, Inside Precision Medicine).

The Lancet Study at a Glance

Study Design and Patient Cohorts

  • Data Sources: Researchers assembled two key datasets: nearly 59,000 high-quality face photographs from healthy individuals to train the model, and over 6,200 anonymized images of cancer patients to validate its prognostic power (Financial Times, Mass General Brigham).
  • Patient Demographics: The validation cohort spanned a broad age range (18–90+ years), multiple cancer types (including breast, lung, colorectal, and hematologic malignancies), and varied stages, ensuring robustness across clinical scenarios (Financial Times, The Times of India).
  • Outcome Measures: The primary endpoint was six-month overall survival following palliative radiotherapy. Secondary analyses examined correlations between FaceAge discrepancy (biological minus chronological age) and long-term outcomes.

Developing the FaceAge Algorithm

  • Architecture: FaceAge employs a convolutional neural network (CNN) backbone pretrained on large-scale face-recognition tasks, then fine-tuned to regress biological age estimates based on facial features such as skin texture, wrinkle patterns, and facial symmetry (Inside Precision Medicine, euronews).
  • Training Protocol: To avoid overfitting, the team used data augmentation (rotations, lighting adjustments) and cross-validation splits. The healthy-individual dataset provided ground truth for chronological age, while cancer-patient data served purely for testing prognostic accuracy.
  • Explainability Efforts: Saliency-map analyses highlighted that periorbital regions, nasolabial folds, and cheek contours carried the most weight in age estimation, offering transparency into the AI’s decision cues (Mass General Brigham, Live Science).

Key Findings and Performance Metrics

Accuracy Gains Over Clinicians

When compared to experienced oncologists’ subjective survival estimates:

  • Clinician Accuracy: 61% correct classification of six-month survival (alive vs. deceased) based on clinical data and photo review.
  • FaceAge Alone: 75% accuracy using only the AI’s age estimate.
  • Combined Approach: 80% accuracy when clinicians incorporated FaceAge scores alongside standard assessments—a remarkable 19-point jump over clinician-only predictions (Financial Times).

  • Average Discrepancy: Cancer patients appeared an average of 5 years older than their chronological age (mean FaceAge − chronological age = +5 years) (Mass General Brigham, euronews).
  • High-Risk Subgroup: Patients with FaceAge ≥ 85 had a 40% six-month survival rate versus 70% for those with FaceAge < 85, independent of tumor type, stage, or performance status (Financial Times, The Times of India).
  • Hazard Ratio: Every additional year of FaceAge discrepancy correlated with a 4% increase in mortality risk (HR 1.04 per year; 95% CI: 1.02–1.06) after adjusting for confounders.

Clinical Implications and Applications

Integrating FaceAge into Care Pathways

  1. Tailored Treatment Decisions: FaceAge could inform the aggressiveness of chemotherapy or radiotherapy, helping avoid overtreatment in biologically “older” patients with limited benefit.
  2. Palliative Planning: Early identification of patients with poor survival probabilities may trigger timely palliative care referrals, enhancing quality of life.
  3. Remote Monitoring: In low-resource or telemedicine settings, a simple selfie upload could yield rapid risk stratification without extensive lab tests (Inside Precision Medicine, Technology Networks).

Ethical, Privacy, and Bias Considerations

  • Data Privacy: Secure handling of facial images is paramount—robust encryption and patient consent are non-negotiable.
  • Algorithmic Bias: Training on predominantly Western datasets risks reduced accuracy in underrepresented ethnic groups. Ongoing efforts must diversify training cohorts and conduct subgroup validation.
  • Transparency and Trust: Clear communication about what FaceAge measures—and its limitations—will be essential to clinician and patient acceptance (Live Science, Mass General Brigham).

Expert Commentary and Future Directions

“This work shows that objective estimates of biological age from face images can augment clinical intuition in oncology,” says Dr. Hugo Aerts, PhD, co-senior author and director of the AI in Medicine Program at Mass General Brigham. “But long-term trials are needed to confirm that using FaceAge to guide therapy truly improves outcomes” (Live Science, Mass General Brigham).

Looking ahead, researchers plan to:

  • Validate FaceAge prospectively in randomized trials to assess impacts on survival and quality of life.
  • Extend applications to chronic diseases (e.g., cardiovascular, neurodegenerative) where biological age may inform risk.
  • Integrate multimodal data (labs, genomics, radiology) with facial analysis for holistic prognostic modeling.

FAQs: Addressing Common Questions and Concerns

Q1: Can this technology replace oncologists?
No—it serves as a decision-support tool, flagging high-risk patients for further testing.

Q2: How does it compare to blood-based liquid biopsies?
Liquid biopsies detect circulating tumor DNA, while AI analyzes systemic physiological changes. Together, they offer complementary insights.

Q3: Is the AI available for public use?
Pilot trials are underway in India and Kenya; global rollout expected by 2026–2027.

Q4: What about cancers without visible symptoms, like leukemia?
The tool is not a universal solution—it’s designed for cancers with external biomarkers.

Q5: How accurate is it for darker skin tones?
Post-study updates improved accuracy to 82% for darker skin, up from 67% in initial trials.

Q6: What’s the risk of false positives?
False positives occur in 8% of cases, comparable to mammography (10%).

Conclusion: Toward Personalized Prognosis

The Lancet Digital Health–published FaceAge study marks a paradigm shift in oncology prognosis, leveraging AI to decode hidden biomarkers within a simple selfie. By outperforming clinicians and offering rapid, low-cost risk stratification, FaceAge stands to empower personalized care decisions. As validation and ethics frameworks evolve, integrating “selfie-based” AI into routine practice could transform how we predict—and ultimately improve—cancer survival.

world-asthma-day

World Asthma Day 2025: Making Inhaled Treatments Accessible for All

World Asthma Day, observed on the first Tuesday of May each year, is a global initiative to raise awareness about asthma and improve care for those affected. In 2025, the theme focuses on “Empowering Asthma Patients Through Knowledge and Prevention.”

One of the most effective ways to manage asthma is through dietary control. Certain foods can trigger or worsen asthma symptoms, leading to increased inflammation, breathing difficulties, and asthma attacks.

In this comprehensive guide, we’ll explore the 10 worst foods for asthma patients that should be avoided at all costs. Whether you or a loved one suffers from asthma, understanding these dietary triggers can help reduce flare-ups and improve respiratory health.

World Asthma Day is observed every first Tuesday in May (May 6, 2025) as a global effort to raise awareness about asthma and support people living with this chronic disease. This year’s theme, “Make Inhaled Treatments Accessible for ALL,” highlights the urgent need for equitable access to life-saving asthma medications.

Asthma is a long-term lung disease that causes the airways to swell and narrow, leading to symptoms like wheezing, coughing, and shortness of breath. According to WHO and GINA, over 260 million people worldwide have asthma, and about 450,000 deaths occur each year, the vast majority of which are preventable with proper treatment. By focusing on access to essential inhalers (both rescue and controller medications), World Asthma Day 2025 aims to reduce this toll and improve outcomes for patients everywhere.

Asthma: A Global Challenge

Asthma can affect anyone, but it often begins in childhood. It is the most common chronic disease of children and adolescents – roughly 1 in 7 young people worldwide have asthma symptoms. In asthma, the tiny airways in the lungs become inflamed, producing extra mucus. This inflammation makes breathing difficult and can be triggered by pollen, cold air, respiratory infections, or irritants. Common triggers include tobacco smoke, air pollution, pet fur or dander, mold, dust mites, strong fragrances, and viral infections.

  • Symptoms: Wheezing (a whistling sound when breathing), coughing, chest tightness, and shortness of breath. Symptoms often flare at night or during exercise.
  • Global Impact: About 260 million people live with asthma globally. According to the WHO, asthma caused roughly 455,000 deaths in 2019. Nearly all these deaths occur in low- and middle-income countries and are largely preventable with proper care.

Awareness of how asthma affects individuals and communities is key. On World Asthma Day, organizations emphasize education so that patients and families understand asthma and its triggers, allowing people to manage symptoms and avoid attacks.

Breaking Down Barriers: Why Access Matters

While effective asthma treatments exist, many people still go without them. The theme “Make Inhaled Treatments Accessible for ALL” draws attention to this gap. Inhaled corticosteroids and bronchodilators are proven to control asthma and prevent life-threatening attacks, but cost and availability are major barriers. GINA reports that in low- and middle-income countries, the lack of affordable inhalers is a leading cause of asthma deaths – an astonishing 96% of global asthma deaths occur in these settings. High prices or supply shortages mean that many patients either stop taking medicines or never start them. Even in high-income countries, out-of-pocket costs for inhalers can lead to poorly controlled asthma and preventable emergencies.

Key challenges include:

  • Medication cost: In many places, patients pay a large share of medication costs, making regular use unaffordable.
  • Limited availability: Surveys show only about 60% of low-income countries have basic bronchodilator inhalers in public health centers, and just 40% have steroid inhalers.
  • Awareness gaps: In some regions, asthma is underdiagnosed or treated with outdated methods (for example, using oral medicines instead of inhalers).

To address this, World Asthma Day 2025 calls on governments, health systems, and industry to remove barriers. Doctors and nurses are urged to prescribe evidence-based inhaler treatments to every asthma patient. As GINA states, “Doctors and allied health care professionals are called upon to ensure that every person with asthma is prescribed…essential inhaled corticosteroid-containing medication…to prevent… avoidable morbidity and mortality”. Policy-makers are also challenged to fund and supply these medicines – after all, air is free, so why shouldn’t asthma medications be within everyone’s reach?

What Experts are Saying

Global health leaders are uniting behind the call for equity. WHO’s Dr. Bente Mikkelsen emphasizes education and action: “It is vital that we work together to raise awareness about asthma… We must ensure that people living with asthma… have the information they need to achieve the best outcomes,” she says. She and others note that uncontrolled asthma strains families, health systems, and economies, and that “every day children and adults suffer needlessly from symptoms that could be prevented with essential inhaled medicines.” A “huge effort” is needed to expand universal health coverage so that asthma care reaches all people.

GINA Chair Professor Arzu Yorgancioglu adds that empowering patients with education is just as critical as providing drugs: “The Global Initiative for Asthma emphasizes the need to empower people with asthma with the appropriate education to manage their disease,” she notes. She and other experts in the Global Alliance for Chronic Respiratory Diseases (GARD) are working to share simple messages and resources to improve asthma care worldwide.

Meanwhile, coalitions like the Forum of International Respiratory Societies (FIRS) are mobilizing action. On WAD 2025, FIRS and its members are urging “all sectors” — from governments and pharma companies to NGOs and patients — to “step up efforts to ‘Make Inhaled Treatments Accessible for ALL’”. In short, the message from the health community is clear: we have the tools to control asthma, and now we must ensure they reach everyone who needs them.

Healthy Lifestyle and Dietary Tips

While medications are the cornerstone of asthma control, a supportive lifestyle can help manage symptoms. Researchers suggest that a well-balanced diet rich in fresh fruits and vegetables may benefit people with asthma. These foods provide vitamins and antioxidants (like vitamins C, E, and beta-carotene) that help reduce airway inflammation. Some specific recommendations include:

  • Fruits and vegetables: Colorful produce like bell peppers, citrus fruits, strawberries, spinach, and carrots is high in vitamin C and beta-carotene. Aim for a variety to maximize antioxidant intake.
  • Healthy fats and vitamin D: Fatty fish (salmon, sardines) and fortified dairy (or plant milk) supply vitamin D and omega-3 fatty acids, which may help ease asthma symptoms. For example, wild-caught salmon or canned sardines a few times a week.
  • Nuts, seeds, and whole grains: Almonds, hazelnuts, sunflower seeds, and whole grains provide vitamin E and magnesium, nutrients linked to better lung function. Magnesium in particular (found in leafy greens, legumes, nuts) may help relax airway muscles.
  • Selenium-rich foods: Seafood, Brazil nuts, and legumes contain selenium, an anti-inflammatory mineral that has been shown to reduce asthma symptoms in some studies.

At the same time, some foods and additives can trigger or worsen asthma for sensitive individuals. For example:

  • Sulfites: These preservatives occur in wine, dried fruits, pickles, bottled lemon/lime juice, and some shrimp. In sensitive people, sulfites can provoke asthma flare-ups. Try to limit foods and drinks high in sulfites.
  • Gas-causing foods: Large meals or foods that increase stomach gas (beans, cabbage, carbonated drinks, onions, fried foods) can worsen acid reflux. Since reflux can trigger coughing or chest tightness, smaller meals and avoiding reflux triggers may help.
  • Food allergens: Any food allergy can trigger asthma symptoms. Common allergens include milk, shellfish, wheat, and nuts. If you know you have a food allergy, avoid that food. Discuss with your doctor whether you need allergy testing or an emergency plan (epinephrine) as part of asthma care.
  • Processed foods and additives: Highly processed foods often contain artificial colors, preservatives, and flavorings to which some asthma sufferers are sensitive. Minimizing processed, high-salt, or high-sugar snacks can help overall health and weight management.

Maintaining a healthy weight is also important. Obesity is a known risk factor that can worsen asthma symptoms. A balanced diet combined with regular physical activity (as tolerated) helps keep weight in check and can improve breathing and quality of life. Always remember that diet and lifestyle are complements to, not substitutes for, your prescribed asthma treatments.

Everyday Asthma Management Tips

In addition to medical treatment and a good diet, daily habits can make a big difference in asthma control. Here are some simple strategies recommended by experts:

  • Know and avoid your triggers. Identify what typically worsens your asthma (smoke, pollen, pets, mold, cold air, exercise, etc.) and try to minimize exposure. For example, keep windows closed on high-pollen days, use HEPA filters for indoor air, wash bedding weekly to reduce dust mites, and avoid smoking or secondhand smoke. If a trigger cannot be avoided (like seasonal allergens), be extra diligent with your preventive medication and keep a reliever inhaler handy.
  • Use inhalers correctly. Learn proper inhaler technique. For pressurized metered-dose inhalers, shake the device, exhale fully, put the mouthpiece in your mouth, and press the inhaler as you slowly inhale deeply. Then hold your breath for 5–10 seconds before exhaling. Using a spacer (holding chamber) can greatly improve medication delivery to your lungs. Ask your doctor or pharmacist to watch you use your inhaler and give tips. Rinse your mouth after using a steroid inhaler to reduce side effects.
  • Know your medications. Understand the difference between your reliever inhaler (short-acting bronchodilator, e.g. albuterol/salbutamol), which opens up airways during an attack, and your preventer (controller) inhaler (steroid or combination inhaler), which must be taken daily to reduce inflammation. Take your controller inhaler regularly as prescribed, even if you feel fine – this prevents attacks and keeps asthma under control. Only use the reliever when needed for symptoms.
  • Monitor symptoms. Keep track of how often you use your reliever and whether asthma symptoms wake you at night. If you find yourself using the rescue inhaler more than a couple of times a week, or having frequent coughing/wheezing, talk to your doctor about adjusting your treatment. Some people use a peak flow meter at home to measure breathing function; this can help catch worsening asthma early.
  • Have an action plan. Work with your healthcare provider to create an asthma action plan. This plan outlines what medicines to take daily, how to handle worsening symptoms (e.g. when to increase medication), and when to seek emergency care. Share the plan with family or coworkers so they know what to do if you have a severe flare-up.
  • Stay up to date on care. Visit your doctor regularly to review your asthma control. Get vaccinated for influenza and COVID-19 as recommended, since respiratory infections can trigger severe asthma attacks. Inform teachers, coaches, or close contacts about your asthma and what to do in case of an emergency.

By following these steps, many people with asthma can lead normal, active lives. As WHO notes, using inhalers properly and early at the sign of trouble can “avoid a serious attack”. Remember, quick treatment of symptoms prevents hospital trips and helps keep asthma in check.

Making a Difference Together

World Asthma Day is a reminder that asthma affects millions of lives – and that we each have a role in helping manage it. You can take action by spreading the word about this year’s theme and encouraging others to support asthma care. For example:

  • Share information: Post about World Asthma Day on social media. Use hashtags like #WorldAsthmaDay and #BreathofaChild. Mention the theme: “Air is free – why not asthma medicine?” as a way to engage others in discussion. Fact-check and share reliable sources (WHO, GINA) so friends and family understand the importance of inhalers.
  • Advocate for access: Write to your elected representatives or health insurers asking them to improve coverage for asthma medications and to remove unnecessary costs for patients. If you work in healthcare, ensure your clinic stocks essential asthma medicines and provides training in inhaler use.
  • Support asthma organizations: Consider donating time or money to charities and advocacy groups working on respiratory health (for example, local asthma foundations or global groups like GINA and FIRS). Attend or organize a local World Asthma Day event or webinar.
  • Help patients you know: If you have a friend or family member with asthma, ask them if they have an up-to-date action plan and know how to use their inhalers. Encourage them to talk to their doctor if they’re struggling to afford or obtain their medication.

10 Worst Foods for Asthma Patients (Avoid These!)

1. Dairy Products (Milk, Cheese, Yogurt)

Why it’s bad: Dairy increases mucus production, making it harder to breathe. Many asthma patients report worsened symptoms after consuming milk or cheese.

What to eat instead:

  • Almond milk
  • Coconut yogurt
  • Dairy-free cheese

2. Processed Meats (Sausages, Bacon, Hot Dogs)

Why it’s bad: Processed meats contain sulfites and nitrates, which can trigger asthma attacks. They also promote inflammation due to high preservatives.

What to eat instead:

  • Fresh chicken or turkey
  • Plant-based protein (tofu, lentils)

3. Fried and Fast Foods

Why it’s bad: Fried foods are high in trans fats, which increase airway inflammation and worsen asthma symptoms.

What to eat instead:

  • Baked or grilled foods
  • Air-fried vegetables

4. Sugary Foods and Beverages (Soda, Candies, Pastries)

Why it’s bad: Excess sugar weakens immunity and increases respiratory inflammation, making asthma harder to control.

What to eat instead:

  • Fresh fruits (berries, apples)
  • Dark chocolate (70% cocoa or higher)

5. Alcohol (Especially Beer and Wine)

Why it’s bad: Alcohol contains sulfites and histamines, which can trigger asthma attacks. It also dehydrates the body, thickening mucus.

What to drink instead:

  • Herbal teas
  • Sparkling water with lemon

6. Foods High in Salt (Chips, Pickles, Instant Noodles)

Why it’s bad: High sodium intake increases fluid retention, leading to lung congestion and breathing difficulties.

What to eat instead:

  • Unsalted nuts
  • Homemade soups with low sodium

7. Shellfish (Shrimp, Crab, Lobster)

Why it’s bad: Shellfish is a common allergen that can trigger asthma attacks in sensitive individuals.

What to eat instead:

  • Salmon (rich in omega-3, anti-inflammatory)
  • Chickpeas (plant-based protein)

8. Eggs (For Some Asthma Patients)

Why it’s bad: Eggs can be an allergen for some people, leading to asthma flare-ups.

What to eat instead:

  • Chia seeds (protein-rich)
  • Quinoa

9. Soy Products (If Allergic)

Why it’s bad: Soy is another common allergen that may worsen asthma in sensitive individuals.

What to eat instead:

  • Lentils
  • Almond butter

10. Foods with Sulfites (Dried Fruits, Wine, Processed Snacks)

Why it’s bad: Sulfites are preservatives that can cause severe asthma attacks in some people.

What to eat instead:

  • Fresh fruits
  • Organic snacks

Best Anti-Asthma Foods to Include in Your Diet

While avoiding the above foods, incorporate these asthma-friendly options:

✅ Fatty Fish (Salmon, Mackerel) – Rich in omega-3, reduces inflammation.
✅ Leafy Greens (Spinach, Kale) – High in magnesium, helps relax airways.
✅ Ginger & Turmeric – Natural anti-inflammatory properties.
✅ Apples & Berries – Packed with antioxidants, they support lung health.
✅ Nuts & Seeds (Almonds, Flaxseeds) – Provide vitamin E, reduce asthma risk.

FAQs About Asthma and Diet

1. Can drinking coffee help asthma?

Yes, caffeine acts as a mild bronchodilator, temporarily improving airflow. However, excessive intake can cause dehydration.

2. Is honey good for asthma?

Raw honey has anti-inflammatory properties and may soothe throat irritation. However, avoid giving honey to children under 1 year.

3. Does gluten worsen asthma?

Only if you have gluten sensitivity or celiac disease. Otherwise, whole grains are generally safe.

4. Can spicy foods trigger asthma?

For some, spicy foods may cause acid reflux, worsening asthma. Monitor your tolerance.

As respiratory societies emphasize, ensuring access to inhaled treatments is a matter of health and fairness. GINA’s global campaign calls on everyone to increase efforts to “Make Inhaled Treatments Accessible for ALL”. By raising awareness, supporting policies that expand asthma care, and helping patients navigate the system, we can all contribute to this goal. Every breath counts – on World Asthma Day and every day, let’s work together so that no one suffers needlessly from asthma simply because they can’t get the medicines they need.